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Because of this, it is hypothesized that trypophobia has an evolutionary basis meant to alert humans of dangerous organisms. Based on the imagery's visual cues, An Trong Dinh Le, Cole and Wilkins developed a symptom questionnaire that they believe can be used to identify trypophobia.
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In a study by Kupfer and Le, trypophobic and non-trypophobic participants showed significant aversion to disease-relevant cluster images, but only trypophobic participants displayed significant aversion to disease-irrelevant cluster images. Whether trypophobia is associated with obsessive—compulsive disorder OCD has also been studied, but a significant minority of those with trypophobia meet the DSM-5 Fort lawn SC milf personals for obsessive—compulsive disorder.
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Writer and editor Kathleen McAuliffe suggested that trypophobia is yet to be extensively studied because researchers have not given as much attention to topics of disgust as they have to other areas of research, and because of the revulsion viewing the images could incite in researchers.